Jason Moffat

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Professor, Donnelly Centre, University of Toronto
Canada Research Chair in Functional Genomics of Cancer

 

Full Biography

 

Cancers of Interest

Skin

 

Research and clinical approaches

Our research is concentrated in three areas:

 

  1. Identification of genetic interactions and differential gene essentiality in mammalian cancer cell lines
  2. Cancer cell surface genes and cellular fitness
  3. Synthetic genetic technologies for exploring gene/protein function and protein-protein interactions in mammalian cells

 

Projects at BioCanRx

Bispecific T-cell engager antibodies targeting CD133+ brain tumor-initiating cells: A novel immunotherapy for recurrent glioblastoma

 

Pre-clinical validation of anti-SIRPα antibodies anti-tumor efficacy through immuno-modulation of macrophages

 

DEVELOPMENT OF IMMUNE REGULATING ANTIBODIES FOR USE IN COMPANION ANIMAL CLINICAL TRIALS

 

Recent Articles

“Heal, boy: How companion animals can help find cures for human cancer” (The Globe and Mail)

 

Put Another Arrow in the Quiver

 

Coming at cancer immunotherapy through macrophages