Jason Moffat

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Professor & Principal Investigator, Department of Molecular Genetics, University of Toronto
Canada Research Chair in Functional Genomics of Cancer

 

Full Biography

 

Cancers of Interest

Skin

 

Research and clinical approaches

Our research is concentrated in three areas:

 

  1. Identification of genetic interactions and differential gene essentiality in mammalian cancer cell lines
  2. Cancer cell surface genes and cellular fitness
  3. Synthetic genetic technologies for exploring gene/protein function and protein-protein interactions in mammalian cells

 

Projects at BioCanRx

Bispecific T-cell engager antibodies targeting CD133+ brain tumor-initiating cells: A novel immunotherapy for recurrent glioblastoma

 

Pre-clinical validation of anti-SIRPα antibodies anti-tumor efficacy through immuno-modulation of macrophages

 

DEVELOPMENT OF IMMUNE REGULATING ANTIBODIES FOR USE IN COMPANION ANIMAL CLINICAL TRIALS

 

Recent Articles

“Heal, boy: How companion animals can help find cures for human cancer” (The Globe and Mail)

 

Put Another Arrow in the Quiver

 

Coming at cancer immunotherapy through macrophages