Project Summaries

Catalyst Projects:


Optimizing a personalized infected cell vaccine (ICV) for peritoneal carcinomatosis
Project lead: Dr. Auer, Rebecca


Validation and manufacturing of anti-BCMA-TACT cells for the treatment of multiple myeloma
Project lead: Dr. Jean-Sebastien Delisle


New generation chimeric antigen receptors for improved adoptive T cell therapy for cancer
Project lead: Dr. Naoto Hirano


Infected Cell Vaccines in the Treatment of Acute Leukemia: Laying the Groundwork for a Clinical Trial
Project lead: Natasha Kekre


Targeted radioligand (tRL) and checkpoint blockade for metastatic castrate resistant prostate cancer
Project lead: Dr. Julian J. Lum


Pre-clinical validation of anti-SIRPα antibodies anti-tumor efficacy through immuno-modulation of macrophages
Project lead: Dr. Sachdev Sidhu


Bispecific T-cell engager antibodies targeting CD133+ brain tumor-initiating cells: A Novel Immunotherapy for Recurrent Glioblastoma
Project lead: Dr. Sheila Singh


Recombinant TCRs and peptide-MHC antibodies to target KRAS hotspot mutations in pancreatic cancer
Project lead: Dr. Simon Turcotte


Enabling Projects:


In vivo human therapeutic cell tracking using a [19F]-perfluorocarbon cellular MRI contrast agent: Phase I feasibility and preliminary safety trial
Project lead: Dr. Gregory Dekaban


Oncolytic vaccinia virus for bladder cancer treatment: preparation for a phase I/II trial
Project lead: Dr. David Evans


Capacity building for Chimeric Antigen Receptor (CAR)-modified T cell therapies in Canada
Project lead: Dr. Rob Holt


Garbage to Gold: expansion of Therapeutic Regulatory T Cells from discarded thymus
Project lead: Dr. Megan Levings

Adoptive T cell therapy targeting patient-specific driver mutations in lymphoma
Project lead: Dr. Brad Nelson


Development of predictive companion biomarkers and therapeutic monitoring for hypermutant cancers to immune checkpoint inhibition
Project lead: Dr. Uri Tabori


Clinical, Social and Economic Impact Projects:


Translational Cancer Immunotherapeutics: Improving the Design, Analysis, and Reporting of Preclinical Studies
Project lead: Dr. Dean Fergusson


Getting better Outcomes with Chimeric Antigen Receptor T-cell therapy (GO–CART): A BioCanRx Research Excelerator to Safely and Effectively Translate CAR-T Cell Therapy for Hematological Malignancies
Project lead: Dr. Manoj Lalu