Project Dashboards

Catalyst Projects:

 

Optimizing a personalized infected cell vaccine (ICV) for peritoneal carcinomatosis
Project lead: Dr. Auer, Rebecca

 

Validation and manufacturing of anti-BCMA-TACT cells for the treatment of multiple myeloma
Project lead: Dr. Jean-Sebastien Delisle

 

New generation chimeric antigen receptors for improved adoptive T cell therapy for cancer
Project lead: Dr. Naoto Hirano

 

Infected Cell Vaccines in the Treatment of Acute Leukemia: Laying the Groundwork for a Clinical Trial
Project lead: Natasha Kekre

 

Targeted radioligand (tRL) and checkpoint blockade for metastatic castrate resistant prostate cancer
Project lead: Dr. Julian J. Lum

 

Pre-clinical validation of anti-SIRPα antibodies anti-tumor efficacy through immuno-modulation of macrophages
Project lead: Dr. Sachdev Sidhu

 

Bispecific T-cell engager antibodies targeting CD133+ brain tumor-initiating cells: A Novel Immunotherapy for Recurrent Glioblastoma
Project lead: Dr. Sheila Singh

 

Recombinant TCRs and peptide-MHC antibodies to target KRAS hotspot mutations in pancreatic cancer
Project lead: Dr. Simon Turcotte

 

Enabling Projects:

 

In vivo human therapeutic cell tracking using a [19F]-perfluorocarbon cellular MRI contrast agent: Phase I feasibility and preliminary safety trial
Project lead: Dr. Gregory Dekaban

 

Oncolytic vaccinia virus for bladder cancer treatment: preparation for a phase I/II trial
Project lead: Dr. David Evans

 

Capacity building for Chimeric Antigen Receptor (CAR)-modified T cell therapies in Canada
Project lead: Dr. Rob Holt

 

Garbage to Gold: expansion of Therapeutic Regulatory T Cells from discarded thymus
Project lead: Dr. Megan Levings

 
Adoptive T cell therapy targeting patient-specific driver mutations in lymphoma
Project lead: Dr. Brad Nelson

 

Development of predictive companion biomarkers and therapeutic monitoring for hypermutant cancers to immune checkpoint inhibition
Project lead: Dr. Uri Tabori

 

Clinical, Social and Economic Impact Projects:

 

Translational Cancer Immunotherapeutics: Improving the Design, Analysis, and Reporting of Preclinical Studies
Project lead: Dr. Dean Fergusson

 

Getting better Outcomes with Chimeric Antigen Receptor T-cell therapy (GO–CART): A BioCanRx Research Excelerator to Safely and Effectively Translate CAR-T Cell Therapy for Hematological Malignancies
Project lead: Dr. Manoj Lalu